We are developing innovative diagnostic and therapeutic strategies for metabolic diseases, cancer, and infections by harnessing the power of the gut microbiome. To achieve this, we generate and integrate multi-omics data—including transcriptomics, single-cell transcriptomics, untargeted metabolomics, and proteomics from the host—together with metagenomics and metatranscriptomics from gut bacteria and fungi. By applying advanced mathematical models, we aim to uncover the intricate mechanisms by which gut microbes contribute to disease or protect against it.
Our access to cutting-edge mouse models and cell lines enables us to experimentally validate key microbe-host interactions, bridging the gap between computational predictions and biological function.
These efforts are supported by the European consortium
MiCCrobioTAckle
and the national consortium
PerMiCCion
, while our participation in the
Cluster of Excellence Balance of the Microverse
allows us to explore fundamental ecological principles governing microbiome assembly and evolution in the human gut.
